San Diego Bus Route 225: Otay Mesa Transit Center to Santa Fe Depot
Otay Mesa Transit Center ↔ Santa Fe Depot
📅 Editorial review: October 2026 | ℹ️ Independent planning guide — not affiliated with MTS | 🎯 Route 225 stops, fares & schedule overview
✅ Official MTS service in San Diego: Route 225 connects Otay Mesa Transit Center with Santa Fe Depot. Buses run from 4:23 AM to 11:10 PM.
📋 Route 225 Essential Information
- Route: 225 — Otay Mesa Transit Center ↔ Santa Fe Depot
- Operator: MTS (San Diego)
- Stops: 12 towards India St & C St; 12 towards Otay Mesa Transit Center
- First departure: 4:23 AM | Last departure: 11:10 PM
- Service: Daily, including weekends
- Fare: Single-ride fare $ 3.00
📖 About Route 225
Route 225 links Otay Mesa Transit Center and Santa Fe Depot. The stop list below is the complete, current MTS pattern, so you can plan boarding and getting off with confidence.
🚏 Route 225 Complete Stop List
Towards India St & C St (from Otay Mesa Transit Center)
- Otay Mesa Transit Center
- Millenia Station
- Otay Ranch Station
- Santa Venetia Station
- Lomas Verdes Station
- Heritage Station
- East Palomar Station
- 14th St & F St
- Broadway & Park Bl
- Broadway & 4th Av
- Broadway & Union St
- India St & C St
Towards Otay Mesa Transit Center (from Santa Fe Depot)
- Santa Fe Depot
- Broadway & 1st Av
- Broadway & 5th Av
- Broadway & Park Bl
- G St & 14th St
- East Palomar Station
- Heritage Station
- Lomas Verdes Station
- Santa Venetia Station
- Otay Ranch Station
- Millenia Station
- Otay Mesa Transit Center
⏰ Route 225 Schedule & Service Hours
Scheduled departures from the terminal (MTS timetable via Transit, verified October 2026):
From Otay Mesa Transit Center towards India St & C St
| Day | First departure | Last departure | Departures | Average interval |
|---|---|---|---|---|
| Saturday | 4:46 AM | 9:16 PM | 31 | ~35 min |
| Monday | 4:23 AM | 9:49 PM | 44 | ~25 min |
From Santa Fe Depot towards Otay Mesa Transit Center
| Day | First departure | Last departure | Departures | Average interval |
|---|---|---|---|---|
| Saturday | 6:08 AM | 10:41 PM | 30 | ~35 min |
| Monday | 5:34 AM | 11:10 PM | 44 | ~25 min |
💵 Fare Information
The single-ride fare on MTS route 225 is $ 3.00 according to the current MTS fare data. Day passes and multi-day passes are usually better value if you ride more than twice — check the agency’s official site or app for the current pass range before you travel.
🗺️ Key Destinations on Route 225
- Millenia Station — transit hub
- Otay Ranch Station — transit hub
- Santa Venetia Station — transit hub
- Lomas Verdes Station — transit hub
- Heritage Station — transit hub
- East Palomar Station — transit hub
- Broadway & Park Bl — park
🧭 How to Ride Route 225 — Step by Step
- Check the schedule below for your direction and get to the stop a few minutes early.
- Have your fare ready — pay on board or use the agency’s official app or card where accepted.
- Signal the driver as the bus approaches and board through the front door.
- Pull the stop-request cord or press the button before your stop and exit through the rear doors.
❓ Frequently Asked Questions
What time does the first 225 bus leave?
The first scheduled departures from the terminals are at 4:23 AM from Otay Mesa Transit Center and 5:34 AM from Santa Fe Depot.
What time is the last 225 bus?
The last scheduled departures are at 9:49 PM from Otay Mesa Transit Center and 11:10 PM from Santa Fe Depot.
Does Route 225 run on weekends?
Yes — the current schedule shows departures every day, including Saturdays and Sundays.
Route and timetable data: MTS via Transit. Independently compiled by the BusUpdate editorial team; confirm time-sensitive details with MTS before travelling. Schedule verified October 2026.